Job Description

Company DescriptionJob Description

This application is for a 6-month student role from January - June 2025. Resume review begins in October 2024.

As a co-op, you will be embedded in Translational In Vivo Sciences group in Integrated Pharmacology & Safety. Our group employs various in vivo techniques including live bioluminescence imaging to evaluate new strategies to improve drug delivery into the central nervous system (CNS) and muscle. We are collaborating with various groups in Biogen to explore new delivery technologies to achieve improved cellular uptake, blood brain barrier penetration, and cell type-specific delivery.

To support Biogen's mission of being pioneers in developing therapeutics against challenging neurological diseases, it is critical to achieve effective drug delivery to the target. Our group is involved in the design and execution of preclinical studies in mouse models to evaluate tissue-enhanced delivery with a particular focus on oligonucleotide therapeutics and gene therapy.

Position Description

You will support in vivo pharmacodynamic studies with either an mRNA readout or bioluminescence readout. A successful candidate will work closely with other team members and acquire the following techniques and skills:

* Dosing in mice via different routes of administration (IP, IV and SC)

* Perform bioluminescence imaging of live mice under anesthesia

* Analyze imaging data and present at lab meetings

* Support other techniques in molecular and cellular biology, such as tissue collection, DNA/RNA purification, digital droplet PCR, tissue sectioning, immunohistochemistry and microscopy

* Gain a thorough understanding of scientific concept of preclinical rodent models and drug delivery

* Take a lead on a subproject to help improve the current in vivo platform

Example projects may include:

* Optimization of a novel brain-specific AAV-luciferase reporter mouse model using in vivo bioluminescence imaging (BLI)

* Optimization of in vivo fluorescence imaging in genetically engineered mouse models

* Validation of a novel genetically engineered mouse model using immunohistochemistry (IHC)

Qualifications

* A basic knowledge of biology/neuroscience

* Scientific curiosity and willingness to learn

* Willingness to handle lab mice on a regular basis

* Basic computer skills, minimally with Microsoft Excel, ideally with analytical software such as GraphPad Prism

* Strong interpersonal skills, ability to clearly communicate scientific results and to maintain detailed written records on ELN

* Hands-on experience with laboratory mice or other research animals is desired

* Previous experience with molecular and cellular biology is a plus

To participate in the Biogen Internship Program, students must meet the following eligibility criteria:

* Legal authorization to work in the U.S.

* At least 18 years of age prior to the scheduled start date

* Be currently enrolled in an accredited community college, college or university

Education

* Current bachelor's degree student in neuroscience or related field.

Additional Information

Why Biogen?

We are a global team with a commitment to excellence, and a pioneering spirit. As a mid-sized biotechnology company, we provide the stability and resources of a well-established business while fostering an environment where individual contributions make a significant impact. Our team encompasses some of the most talented and passionate achievers who have unparalleled opportunities for learning, growth, and expanding their skills. Above all, we work together to deliver life-changing medicines, with every role playing a vital part in our mission. Caring Deeply. Achieving Excellence. Changing Lives.

At Biogen, we are committed to building on our culture of inclusion and belonging that reflects the communities where we operate and the patients we serve. We know that diverse backgrounds, cultures, and perspectives make us a stronger and more innovative company, and we are focused on building teams where every employee feels empowered and inspired. Read on to learn more about our DE&I efforts.

All qualified applicants will receive consideration for employment without regard to sex, gender identity or expression, sexual orientation, marital status, race, color, national origin, ancestry, ethnicity, religion, age, veteran status, disability, genetic information or any other basis protected by federal, state or local law. Biogen is an E-Verify Employer in the United States.

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