The Black Stars are top of Group E after Thursday’s win over Palencas Negras.
The 33-year-old had complained of pain in the early hours of Saturday morning and tests confirmed he had hurt his knee on Thursday.
According to GFA’s Director of Communications, Henry Asante Twome, “He came in this morning complaining of a knee injury. The team doctor carried out preliminary tests on him and concluded that he would need to return to England for further scans.
The Nottingham Forest man will not travel with the squad to Luanda after his team doctor gave the go-ahead.
Mohamed Salisu, Denis Odoi and Alexander Ziku have also been ruled out of the Angola match on Monday due to injury.